Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity
نویسندگان
چکیده
منابع مشابه
Sodium pyrophosphate inhibition of RNA.DNA hybrid degradation by reverse transcriptase.
Sodium pyrophosphate inhibits synthesis of anticomplementary DNA during a reverse transcriptase (RNA-directed DNA nucleotidyltransferase, EC 2.7.7.7) catalyzed reaction. In the presence of pyrophosphate, the complementary DNA remains stably complexed to the RNA template. In the absence of pyrophosphate, the DNA. RNA hybrid template is degraded and anticomplementary DNA is synthesized. High conc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2016
ISSN: 0021-9258
DOI: 10.1074/jbc.m116.753152